Rbm38 in cancer: role and mechanism

WebMETHODS: In the present study, we investigated the role and molecular mechanism of misregulation in the p53-mdm2 loop function by RBM38 in HCC. First we investigated the correlation of RBM38 activity and p53-mdm2 loop function in liver cancer cells and HCC tissues by western blot and quantitative RT-PCR. WebApr 12, 2024 · Fig. 1: USP1 is an important regulator of Hippo signaling activity, and its expression is elevated in human hepatocellular carcinoma. A The flowchart shows the siRNA screening procedure for ...

Molecular Landscape of Induced Reprogramming: A Dissertation

WebJul 8, 2024 · Here, we review the evidence that RBM38, an intensively studied RBP, frequently plays a tumor-suppressive role in multiple human cancer types. Genetic studies … WebThis reduction was shown to require the N- and C-terminal regions of Rbm38, along with an important role being played by the RNA-recognition motif of Rbm38. ... Cancer Res. 2014, 12, 359–369. ... A schematic model of the mechanism by which Rbm38 suppresses the transcription defect caused by splicing deficiency. cs pro it services gmbh https://pmellison.com

RBM38 Is a Direct Transcriptional Target of E2F1 that Limits E2F1 ...

WebApr 8, 2024 · Extrachromosomal circular DNAs (eccDNAs) participate in tumorigenesis and tumor progression. However, the role and mechanism of eccDNAs have yet to be elucidated in non-small cell lung cancer (NSCLC). WebThis reduction was shown to require the N- and C-terminal regions of Rbm38, along with an important role being played by the RNA-recognition motif of Rbm38. ... Cancer Res. 2014, … WebMar 15, 2024 · Cancer cells are known to adapt a few alternate pathways to maintain cellular iron balance. In NSCLS (non-small cell lung carcinoma cells) EGFR, growth factor that regulates growth, survival, proliferation and differentiation in mammalian cells has been demonstrated to affect iron metabolism by directly binding and redistributing TfR-1 [41,44]. csproj add reference

RBM38 Is a Direct Transcriptional Target of E2F1 that Limits E2F1 ...

Category:ZFP14 Regulates Cancer Cell Growth and Migration by Modulating …

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Rbm38 in cancer: role and mechanism

RBM38 in cancer: role and mechanism SpringerLink

WebCROSS-REFERENCE TO RELATED APPLICATIONS. This application is a Continuation of U.S. patent application Ser. No. 16/649,732, filed Mar. 23, 2024, which is a national stage filing u WebApr 11, 2024 · Moreover, specific inhibitors of c-Myc transcriptional activity inhibited RBM38-induced suppression of growth, implying that RBM38 acts as a tumor suppressor …

Rbm38 in cancer: role and mechanism

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WebHere, we review the evidence that RBM38, an intensively studied RBP, frequently plays a tumor-suppressive role in multiple human cancer types. Genetic studies in mice deficient … WebZou, C., Wan, Y., He, L., Zheng, J. H., Mei, Y., Shi, J., … Zhang, D. (2024). RBM38 in cancer: role and mechanism. Cellular and Molecular Life Sciences. doi:10.1007 ...

WebAutophagy plays a complex role in tumor cells; studies have shown that autophagy can both inhibit cancer onset and promote advanced tumor growth. 4 Increasing evidence shows that cancer cells are more dependent on autophagy than normal cells, and this dependence may be further strengthened during the treatment process. 5 An increasing number of research … WebTo systemically study the role of RBPs in BAT, we profiled >400 RBPs in different adipose depots and identified Y-box binding protein 2 (Ybx2) as a novel regulator in BAT activation.

Web10 hours ago · AR plays a critical role in the development and progression of prostate cancer, particularly in its metastatic form. AR is a transcription factor, which means it … WebOct 1, 2024 · Despite their abundance and several large-scale studies showing their contribution to the evolution of gene-regulatory networks, their role in physiology and various diseases, including cancer, remains relatively rare [2,7,8]. The tumor suppressor p53 is the most commonly mutated gene in human cancers.

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WebRetired husband syndrome (主人 在 宅ストレス症候群, Shujin Zaitaku Sutoresu Shoukougun, literally "One's Husband Being at Home Stress Syndrome")[1] (RHS) is a psychosomatic stress-related illness which has been estimated to occur in 60% of Japan's older female population.[2] It is a condition where a woman begins to exhibit signs of physical illness … cs professional tax noteshttp://lcgdbzz.org/en/article/doi/10.3969/j.issn.1001-5256.2024.04.032 ealynsWebSep 3, 2024 · Methods: In the present study, we investigated the role and molecular mechanism of misregulation in the p53-mdm2 loop function by RBM38 in HCC. First we … csproj add package referenceWebDec 1, 2024 · PDF Background: Misregulation of the p53-mdm2 loop function is a major mechanism to promote hepatocellular carcinoma (HCC). RBM38, a member of the... … ealyn\\u0027s giftWebAug 22, 2024 · Breast cancer is the most common malignancy in females worldwide (Chen et al, 2016; Siegel et al, 2016), and the metastasis accounts for the majority of deaths from breast cancer.One potential mechanism for invasion and metastasis in breast cancer is due to the occurring of epithelial–mesenchymal transition (EMT) that allows the polarised … ealyns summonWebApr 10, 2024 · The alpha-thalassemia mental retardation X-linked (ATRX) syndrome protein is a chromatin remodeling protein that primarily promotes the deposit of H3.3 histone … ealyns gift powerpassWebRecent breakthroughs in creating induced pluripotent stem cells (iPS cells) provide alternative means to obtain embryonic stem (ES) cell-like cells without destroying embryos by introducing four reprogramming factors (Oct3/4, Sox2, and Klf4/c-Myc or ealyn\u0027s summon