WebMETHODS: In the present study, we investigated the role and molecular mechanism of misregulation in the p53-mdm2 loop function by RBM38 in HCC. First we investigated the correlation of RBM38 activity and p53-mdm2 loop function in liver cancer cells and HCC tissues by western blot and quantitative RT-PCR. WebApr 12, 2024 · Fig. 1: USP1 is an important regulator of Hippo signaling activity, and its expression is elevated in human hepatocellular carcinoma. A The flowchart shows the siRNA screening procedure for ...
Molecular Landscape of Induced Reprogramming: A Dissertation
WebJul 8, 2024 · Here, we review the evidence that RBM38, an intensively studied RBP, frequently plays a tumor-suppressive role in multiple human cancer types. Genetic studies … WebThis reduction was shown to require the N- and C-terminal regions of Rbm38, along with an important role being played by the RNA-recognition motif of Rbm38. ... Cancer Res. 2014, 12, 359–369. ... A schematic model of the mechanism by which Rbm38 suppresses the transcription defect caused by splicing deficiency. cs pro it services gmbh
RBM38 Is a Direct Transcriptional Target of E2F1 that Limits E2F1 ...
WebApr 8, 2024 · Extrachromosomal circular DNAs (eccDNAs) participate in tumorigenesis and tumor progression. However, the role and mechanism of eccDNAs have yet to be elucidated in non-small cell lung cancer (NSCLC). WebThis reduction was shown to require the N- and C-terminal regions of Rbm38, along with an important role being played by the RNA-recognition motif of Rbm38. ... Cancer Res. 2014, … WebMar 15, 2024 · Cancer cells are known to adapt a few alternate pathways to maintain cellular iron balance. In NSCLS (non-small cell lung carcinoma cells) EGFR, growth factor that regulates growth, survival, proliferation and differentiation in mammalian cells has been demonstrated to affect iron metabolism by directly binding and redistributing TfR-1 [41,44]. csproj add reference