WebDownload scientific diagram The GPS enzyme GPD2 regulates glucose oxidation in LPS-activated macrophages a, Global steady-state metabolite profiling of BMDMs, unstimulated or LPS-stimulated for ... WebInhibiting PKCδ or GPD2 pT10 in glioma cells or blocking IL-1β generated by macrophages attenuated the glycolytic rate and proliferation of glioma cells. Furthermore, human …
GPD2 protein expression summary - The Human Protein Atlas
WebHere we find that in macrophages activated by bacterial lipopolysaccharide (LPS), mitochondrial glycerol 3-phosphate dehydrogenase (GPD2) regulates glucose oxidation to drive inflammatory responses. GPD2, a component of the glycerol phosphate shuttle, boosts glucose oxidation to fuel the production of acetyl coenzyme A, acetylation of histones ... Webhibitor. Furthermore, the use of macrophages derived from GPD2 knockout mice indicated that glucose is indispensable for suppress-ing macrophage oxidative metabolism and inflammatory gene in-duction even in a tolerant state after LPS stimulation. These toler-ance responses occurred in a GPD2-dependent manner. short modern hairstyles for older women
National Center for Biotechnology Information
WebApr 1, 2024 · Therefore, approaches directly impacting monocyte/macrophage recruitment, macrophage activation, and/or macrophage functions and polarization are the most investigated 3,9. Our data demonstrate ... WebSep 24, 2024 · Author Correction: Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses Nature Immunology Author Correction Published: 24 September 2024 Author Correction:... WebFeb 10, 2024 · Macrophages are crucial effector cells of the innate immune system and have important roles in the initiation and resolution of inflammation as well as in tissue homeostasis. To fulfill these diverse roles, macrophages exhibit metabolic flexibility to quickly adapt to the needs of the effector functions required, as well as to the … sanskara wellness sanctuary and eatery